Many of the most well-validated and essential potential drug targets remain elusive from synthetic molecule-based drug discovery. These include arguably the most important classes of drug targets, such as protein-protein interactions, (non-steroidal) transcription factors, and other nucleic acid complexes. It is well established that 4 billion years of evolution through interactions enabled soil microorganisms to develop the ability to produce scaffolds that can be utilized as human medications in terms of size and therapeutic characteristics. These scaffolds are not produced as a collaborative effort with the human race but as a means for biological interaction among neighboring microorganisms. Current drug discovery methodologies fail to utilize 99.9% of this promising potential. Terrapeutics has found a way to tap into this huge pool of therapeutic solutions to find molecules that aim at "undruggable" drug targets.  This unique ability has the potential to transform drug discovery.